DIAPHRAGM: Long-Term Outcomes
Diaphragm Thickness in Mechanically Ventilated Patients: Long-Term Outcomes
Study Investigators
Jenna Wong (ext. 7613, jenna.wong@uhn.ca)
Dr. Ewan Goligher (ext. 6810, ewan.goligher@uhn.ca)
Dr. Hannah Wunsch
Study Contact
Jenna Wong (ext. 7613, jenna.wong@uhn.ca)
Study Summary
A retrospective study aiming to assess the relationship between structural changes in the diaphragm during the early course of mechanical ventilation and long-term outcomes in ICU survivors.
Study Population
Patients who participated in the DIAPHRAGM study and survived to hospital discharge.
Study Objectives
Explore the relationship between changes in diaphragm thickness during mechanical ventilation and long-term clinical outcomes.
Assess the relationship between diaphragm injury (defined by changes in diaphragm thickness) while on mechanical ventilation and post-ICU functional outcomes.
Study Interventions
The relationship between early changes in diaphragm thickness collected in the DIAPHRAGM study and functional outcomes collected in the TOWARDS RECOVER study will be assessed and compared. ICU discharge destination, readmission to hospital and healthcare services sought after initial hospital discharge will be retrieved from the ICES database, and examined in patients who previously participated in the DIAPHRAGM study.
Why it Matters
The relationship between changes in the diaphragm during the early course of mechanical ventilation and the probability of long-term disability is unknown. Characterizing the impact of ventilator-induced diaphragm injury on long-term functional abilities would provide important insights into the possible strategies for prevention.