The RADAR Study
Study Investigators
Dr. Benjamin Coiffard (benjamin.coiffard@uhn.ca)
Dr. Dmitry Rozenberg
Dr. Niall Ferguson
Dr. Ewan Goligher (ext. 6810, ewan.goligher@uhn.ca)
Study Contact
Jenna Wong (jenna.wong@uhn.ca)
Study Summary
Prospective observational study aiming to characterize the changes in diaphragm function after lung transplantation (LTx).
Study Population
1100 patients who underwent LTx at the Toronto General Hospital.
Study Objectives
Characterize the incidence of diaphragm dysfunction at the first spontaneous breathing trial and at day 7 after LTx.
Determine if pre-transplant diaphragm thickness, function and muscle mass may predict post-transplant diaphragm dysfunction.
Evaluate whether post-transplant diaphragm dysfunction is associated with poor early outcomes after LTx.
Study Interventions
The study team will assess diaphragm and abdominal muscles structure and function (by CT-scan, ultrasound, and PFTs) prior transplantation, on a daily basis for up to 1 week and at 3 months after transplantation.
Why it Matters
Diaphragm dysfunction is a well-known complication after LTx. The incidence of diaphragm dysfunction was reported between 3% and 30% in the literature, with consequences mainly on the duration of mechanical ventilation and post-transplant hospitalization. Characterizing pre-transplant predictive factors associated with diaphragm dysfunction accounting for the morphological and functional sonographic changes of the diaphragm would provide important mechanistic insights into the clinical and physiological importance of (and possible strategies for preventing before LTx) these changes.